Drug Sensitivity (MDR1)
all concerned, a test not to be taken lightly
What is drug sensitivity?
The administration of certain drugs, even at normal doses, leads to neurotoxicity in dogs with drug sensitivity of genetic origin.
When the MDR1 (MultiDrug Resistance) gene is mutated, the corresponding protein (MDR1-PGP), whose function is to expel toxic molecules out of the central nervous system, is inactive (It cannot then fulfill its function neuroprotective)
Is my dog in danger?
The Australian Shepherd is one of the TOP 3 breeds at high risk (or moderate).
This is why it is essential to have the reflex to test your dogs and despite this test even if the dog is normal Homozygote or Heterozygote it will be necessary to pay attention to the dangerous molecules of certain drugs.
Buying a puppy is not a game and must be taken seriously. The genetics are precise but not flawless so you must take as many precautions as possible and warn your veterinarian of the risk of intoxication so that he can take measures and adapt the treatments.
Are there clinical signs and why screen?
After the administration of a risk drug, depending on the dose, a sensitive dog presents a neurosuppressive syndrome with the following clinical signs: ataxia, prostration, paresis, hypersalivation, mydriasis, amaurosis, tremors, convulsions which can lead to coma or to death from respiratory depression.
There is preventive screening:
Adapt your prescription with an alternative treatment, safe for the health of the animal (ask your veterinarian)
Indicate on the animal's health record its genetic status with regard to drug sensitivity
And you confirm a diagnosis with an MDR1 test and report the case to the veterinary pharmacovigilance device.
all information about genetic testing: https://www.antagene.com/fr